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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHEK1 All Species: 35.15
Human Site: Y227 Identified Species: 55.24
UniProt: O14757 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14757 NP_001107593.1 476 54420 Y227 D W K E K K T Y L N P W K K I
Chimpanzee Pan troglodytes XP_001145968 476 54387 Y227 D W K E K K T Y L N P W K K I
Rhesus Macaque Macaca mulatta XP_001111357 476 54432 Y227 D W K E K K T Y L N P W K K I
Dog Lupus familis XP_852191 460 52810 Y211 D W K E K K T Y L N P W K K I
Cat Felis silvestris
Mouse Mus musculus O35280 476 54363 Y227 D W K E K K T Y L N P W K K I
Rat Rattus norvegicus Q91ZN7 476 54410 Y227 D W K E K K T Y L N P W K K I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513209 476 53924 Y227 D W K E K K T Y L P P W K K I
Chicken Gallus gallus Q8AYC9 476 53830 Y227 D W K E R K T Y L A P W R K I
Frog Xenopus laevis Q6DE87 474 53957 H226 C D W K E K N H Y L T P W K K
Zebra Danio Brachydanio rerio NP_956487 410 46756 Y178 D W L E R K T Y L T P W K K I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O61661 512 57815 W239 N W R D N D H W Q L Q T P W S
Honey Bee Apis mellifera XP_623436 467 53927 M225 A W R D G K Y M S L T P W K K
Nematode Worm Caenorhab. elegans Q9N3Z3 503 56917 L247 G W I S N T S L D E R P W K K
Sea Urchin Strong. purpuratus NP_001091925 468 52554 H227 D W L D K K M H L S P W K K I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84VQ3 439 49610 Q188 A P E V L N D Q G Y D G A T A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.3 93.2 N.A. 93.2 94.3 N.A. 89.9 84.4 77.7 56.9 N.A. 46 45.5 32 57.9
Protein Similarity: 100 100 99.7 95.1 N.A. 97 97.2 N.A. 95.3 91.5 86.7 71 N.A. 62.8 63.8 48.7 73.3
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 80 13.3 80 N.A. 6.6 20 13.3 66.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 93.3 33.3 86.6 N.A. 33.3 33.3 20 86.6
Percent
Protein Identity: N.A. N.A. N.A. 32.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 52.1 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 0 0 0 0 0 0 0 0 7 0 0 7 0 7 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 67 7 0 20 0 7 7 0 7 0 7 0 0 0 0 % D
% Glu: 0 0 7 60 7 0 0 0 0 7 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 7 0 0 0 7 0 0 0 7 0 0 7 0 0 0 % G
% His: 0 0 0 0 0 0 7 14 0 0 0 0 0 0 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 67 % I
% Lys: 0 0 54 7 54 80 0 0 0 0 0 0 60 87 20 % K
% Leu: 0 0 14 0 7 0 0 7 67 20 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 7 7 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 14 7 7 0 0 40 0 0 0 0 0 % N
% Pro: 0 7 0 0 0 0 0 0 0 7 67 20 7 0 0 % P
% Gln: 0 0 0 0 0 0 0 7 7 0 7 0 0 0 0 % Q
% Arg: 0 0 14 0 14 0 0 0 0 0 7 0 7 0 0 % R
% Ser: 0 0 0 7 0 0 7 0 7 7 0 0 0 0 7 % S
% Thr: 0 0 0 0 0 7 60 0 0 7 14 7 0 7 0 % T
% Val: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 87 7 0 0 0 0 7 0 0 0 67 20 7 0 % W
% Tyr: 0 0 0 0 0 0 7 60 7 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _